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Article

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.

Expert opinion on therapeutic targets - 1 Feb 2017

Waløen Kai, Kleppe Rune, Martinez Aurora, Haavik Jan

Abstract excerpt

INTRODUCTION: The ancient and ubiquitous monoamine signalling molecules serotonin, dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions. The aromatic amino acid hydroxylases tyrosine hydroxylase (TH), tryptophan hydroxylase 1 (TPH1), and tryptophan hydroxylase 2 (TPH2) catalyse the rate-limiting steps in the biosynthesis of these monoamines. Genetic variants of TH, TPH1, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27973928
DOI: 10.1080/14728222.2017.1272581

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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