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Article

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

The American journal of gastroenterology - 1 May 2009

Schoultz Ida, Verma Deepti, Halfvarsson Jonas, Törkvist Leif, Fredrikson Mats, Sjöqvist Urban, Lördal Mikael, Tysk Curt, Lerm Maria, Söderkvist Peter, Söderholm Johan D

Abstract excerpt

OBJECTIVES: Crohn's disease (CD) is characterized by overproduction of proinflammatory cytokines like interleukin (IL)-1beta. Production of mature IL-1beta is dependent on a caspase-1-activating protein complex called the NALP3 inflammasome, composed of NALP3, ASC, and CARD8. NALP3 shares structural similarities with Nod2, and both of these proteins are required for bacteria-induced IL-1beta secretion. The...

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Source

Identifiers

PMID: 19319132
DOI: 10.1038/ajg.2009.29

Genes

CARD8

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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