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Article

Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis.

Scandinavian journal of rheumatology - 1 Jan 2013

Kastbom A, Klingberg E, Verma D, Carlsten H, Forsblad-d'Elia H, Wesamaa J, Cedergren J, Eriksson P, Söderkvist P

Abstract excerpt

OBJECTIVES: The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome is important for interleukin-1beta (IL-1β) processing as part of an innate immune response. Caspase recruitment domain family, member 8 (CARD8) is an inhibitor of nuclear factor kappa B (NF-κB) and possibly a...

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Source

Identifiers

PMID: 23547871
DOI: 10.3109/03009742.2013.779020

Genes

CARD8
NLRP3
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23547871-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis.PMID 23547871Read ↗

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Association of CARD8 with inflammatory bowel disease in Koreans.Semantic proximity Read ↗

Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study.Semantic proximity Read ↗

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Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.Semantic proximity Read ↗

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