Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.

PloS one - 1 Jan 2013

Sahdo Berolla, Fransén Karin, Asfaw Idosa Berhane, Eriksson Per, Söderquist Bo, Kelly Anne, Särndahl Eva

Abstract excerpt

BACKGROUND: The NLRP3 inflammasome has been recognized as one of the key components of the innate immunity by sensing a diversity of insults. Inflammasome activation results in the maturation of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Increased production of IL-1β is found in patients with gain-of-function polymorphisms in genes encoding the NLRP3 inflammasome. Since approximately 5% of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Donors
Share to CARD Signaling Adaptor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Cytokines

Share to Health

Share to Inflammasomes

Share to Neoplasm Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24098386
DOI: 10.1371/journal.pone.0075457
PMCID: PMC3789710

Genes

NLRP3
CARD8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome.PMID 24098386Read ↗

The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.Semantic proximity Read ↗

Inflammatory Cytokine response in a cohort of patients carrying novel NLRP12 variantsSemantic proximity Read ↗

Genetic contribution and functional impairment of inflammasome in sickle cell disease.Semantic proximity Read ↗

Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility.Semantic proximity Read ↗

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.Semantic proximity Read ↗

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Semantic proximity Read ↗

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortalitySemantic proximity Read ↗

Multifactorial Activation of NLRP3 Inflammasome: Relevance for a Precision Approach to Atherosclerotic Cardiovascular Risk and DiseaseSemantic proximity Read ↗

Increased Prevalence of NLRP3 Q703K Variant Among Patients With Autoinflammatory Diseases: An International Multicentric Study.Semantic proximity Read ↗

Clinical presentation and cytokine production abnormalities in a cohort of patients carrying NLRP12 gene variantsSemantic proximity Read ↗

NLRP3-Inflammasome Gene Variations in the Risk of Type 2 Diabetes.Semantic proximity Read ↗

Inflammasome and IL-1β-Mediated DisordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.