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Article

The genetics of NOD-like receptors in Crohn's disease.

Tissue antigens - 1 Jul 2010

Cummings J R Fraser, Cooney R M, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon L R, Jewell D P

Abstract excerpt

The first Crohn's disease (CD) susceptibility gene identified was CARD15, which is a member of the emerging NOD-like receptor (NLR) family. These function as intracellular cystosolic pattern recognition receptors (PRRs) and play a central role in the innate immune response. We studied other membe...

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Source

Identifiers

PMID: 20403135
DOI: 10.1111/j.1399-0039.2010.01470.x

Genes

NLRP1
NLRP11
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20403135-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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