Article
Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.
Diabetes & vascular disease research - 1 Jan 2000
Tsetsos Fotis, Roumeliotis Athanasios, Tsekmekidou Xanthippi, Alexouda Sophia, Roumeliotis Stefanos, Theodoridis Marios, Thodis Elias, Panagoutsos Stylianos, Papanas Nikolaos, Papazoglou Dimitrios, Kotsa Kalliopi, Yovos John G, Maltezos Efstratios, Passadakis Ploumis, Paschou Peristera, Georgitsi Marianthi
Abstract excerpt
BACKGROUND: Approximately one third of type 2 diabetes mellitus (T2DM) cases present with diabetic nephropathy (DN), the leading cause of end-stage renal disease. Inflammation plays an important role in T2DM disease and DN pathogenesis. NLRP3 inflammasomes are complexes that regulate interleukin-1B (IL-1B) and IL-18 secretion, both involved in inflammatory responses. Activation of NLRP3 is associated with DN...
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