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Article

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.

Nature genetics - 1 Jan 2009

Villani Alexandra-Chloé, Lemire Mathieu, Fortin Geneviève, Louis Edouard, Silverberg Mark S, Collette Catherine, Baba Nobuyasu, Libioulle Cécile, Belaiche Jacques, Bitton Alain, Gaudet Daniel, Cohen Albert, Langelier Diane, Fortin Paul R, Wither Joan E, Sarfati Marika, Rutgeerts Paul, Rioux John D, Vermeire Severine, Hudson Thomas J, Franchimont Denis

Abstract excerpt

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3) that are associated with Crohn's disease. The associations were consistently replicated in four sample sets from individuals of European descent. In the combined analysis of all samples (710 father-mother-child trios, 239 cases and 107...

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Source

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Identifiers

PMID: 19098911
DOI: 10.1038/ng.285
PMCID: PMC2728932

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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