Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease.

International journal of molecular sciences - 20 Feb 2023

La Russa Antonella, Lofaro Danilo, Montesanto Alberto, La Russa Daniele, Zaza Gianluigi, Granata Simona, Di Dio Michele, Serra Raffaele, Andreucci Michele, Bonofiglio Renzo, Perri Anna

Abstract excerpt

Nod-like receptor protein 3 (NLRP3) is a multi-protein complex belonging to the innate immune system, whose activation by danger stimuli promotes inflammatory cell death. Evidence supports the crucial role of NLRP3 inflammasome activation in the transition of acute kidney injury to Chronic Kidney Disease (CKD), by promoting both inflammation and fibrotic processes. Variants of NLRP3 pathway-related genes, such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to CARD Signaling Adaptor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Neoplasm Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Polymorphism, Single Nucleotide

Share to Renal Dialysis

Share to Renal Insufficiency, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 36835594
DOI: 10.3390/ijms24044184
PMCID: PMC9963401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between NLRP3 rs10754558 and CARD8 rs2043211 Variants and Susceptibility to Chronic Kidney Disease.PMID 36835594Read ↗

Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.Semantic proximity Read ↗

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Semantic proximity Read ↗

The Role of NLRP3 Inflammasome in Lupus Nephritis.Semantic proximity Read ↗

Association of CARD8 with inflammatory bowel disease in Koreans.Semantic proximity Read ↗

The association between single nucleotide polymorphisms in NLRP gene and diabetic nephropathy.Semantic proximity Read ↗

NLRP3-Inflammasome Gene Variations in the Risk of Type 2 Diabetes.Semantic proximity Read ↗

The current role of NLRP3 inflammasome polymorphism in gout susceptibility.Semantic proximity Read ↗

Donor and recipient genetic variants in NLRP3 associate with early acute rejection following kidney transplantation.Semantic proximity Read ↗

The Association between Polymorphism of CARD8 rs2043211 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male Population.Semantic proximity Read ↗

The Association between Polymorphism of NLRP3 rs10754558 and Susceptibility to Arteriosclerosis Obliterans in Chinese Han Male PopulationSemantic proximity Read ↗

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.Semantic proximity Read ↗

NALP3 inflammasome functional polymorphisms and gout susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.