Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease.

Genes and immunity - 1 Jun 2010

Roberts R L, Topless R K G, Phipps-Green A J, Gearry R B, Barclay M L, Merriman T R

Abstract excerpt

The location of CARD8 within an inflammatory bowel disease (IBD) locus and its role in the NALP3 inflammasome and as a nuclear factor (NF)kappaB inhibitor make it an attractive candidate risk gene for IBD. However, studies testing for the association of the CARD8 loss-of-function single-nucleotid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CARD Signaling Adaptor Proteins
Share to Carrier Proteins
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Neoplasm Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Nod2 Signaling Adaptor Protein

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 20182451
DOI: 10.1038/gene.2010.11

Genes

CARD8
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20182451-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease.PMID 20182451Read ↗

Association of CARD8 with inflammatory bowel disease in Koreans.Semantic proximity Read ↗

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.Semantic proximity Read ↗

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.Semantic proximity Read ↗

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Genetic variation in CARD8, a gene coding for an NLRP3 inflammasome-associated protein, alters the genetic risk for diabetic nephropathy in the context of type 2 diabetes mellitus.Semantic proximity Read ↗

Association between CARD8 rs2043211 polymorphism and inflammatory bowel disease: a meta-analysis.Semantic proximity Read ↗

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.Semantic proximity Read ↗

Is the CARD8 rs2043211 polymorphism associated with susceptibility to Crohn's disease? A meta-analysis.Semantic proximity Read ↗

IBD: Dysbiosis underlies CARD9 risk alleles in colitis.Semantic proximity Read ↗

The genetics of NOD-like receptors in Crohn's disease.Semantic proximity Read ↗

Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel.Semantic proximity Read ↗

Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.