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Article

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease.

Mediators of inflammation - 1 Jan 2015

Paramel G V, Sirsjö A, Fransén K

Abstract excerpt

The complexity of a common inflammatory disease is influenced by multiple genetic and environmental factors contributing to the susceptibility of disease. Studies have reported that these exogenous and endogenous components may perturb the balance of innate immune response by activating the NLRP3 inflammasome. The multimeric NLRP3 complex results in the caspase-1 activation and the release of potent inflammatory...

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Share to CARD Signaling Adaptor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25788762
DOI: 10.1155/2015/846782
PMCID: PMC4348606

Genes

NLRP3
CARD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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