Article
The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts.
BMC developmental biology - 3 Feb 2015
Yamamoto Takayoshi, Tsukahara Tatsuya, Ishiguro Tadashi, Hagiwara Haruo, Taira Masanori, Takeda Hiroyuki
Abstract excerpt
BACKGROUND: Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to be lower in fish than in mice, suggesting the presence of species-specific mechanisms for Hh signal transduction. RESULTS: To precisely understand the role of cilia in Hh signaling in fish and...
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