Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.

PloS one - 1 Jan 2009

Hennah William, Porteous David

Abstract excerpt

BACKGROUND: Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes. METHODOLOGY: Here, we analyze public...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic Nucleotide Phosphodiesterases, Type 3
Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Databases, Factual

Share to Gene Regulatory Networks

Share to Mental Disorders

Share to Microtubule-Associated Proteins

Share to Perception

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 19300510
DOI: 10.1371/journal.pone.0004906
PMCID: PMC2654149

Genes

DISC1
NDE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.PMID 19300510Read ↗

DISC1 genetics, biology and psychiatric illnessSemantic proximity Read ↗

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.Semantic proximity Read ↗

DISC1 at 10: connecting psychiatric genetics and neuroscience.Semantic proximity Read ↗

Role of DISC1 in neural development and schizophrenia.Semantic proximity Read ↗

Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.Semantic proximity Read ↗

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.Semantic proximity Read ↗

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic ImagingSemantic proximity Read ↗

Disrupted‐in‐Schizophrenia‐1 (DISC1)Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophreniaSemantic proximity Read ↗

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.Semantic proximity Read ↗

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.