Article
Role of DISC1 in neural development and schizophrenia.
Current opinion in neurobiology - 1 Feb 2007
Mackie Shaun, Millar J Kirsty, Porteous David J
Abstract excerpt
How can we hope to explain mechanistically the schizophrenic phenotype? Perhaps through the reductionist approach of genetics, which is beginning to yield biological clues. Growing evidence supports the view that the well-established genetic risk factor DISC1 plays an important role in schizophrenia biology by interacting with FEZ1 and NDEL1 during neurodevelopment and with the phosphodiesterase PDE4B in neuronal...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Adaptor Proteins, Signal Transducing
- Animals
- Brain
- Carrier Proteins
- Cyclic Nucleotide Phosphodiesterases, Type 4
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Genetic Predisposition to Disease
- Humans