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Article

Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.

Endocrine - 1 Jun 2009

Shi Zhiyong, Liu Jing, Guo Qian, Ma Xiaoqin, Shen Linna, Xu Sanni, Gao Hongxia, Yuan Xinjian, Zhang Junling

Abstract excerpt

BACKGROUND: TRB3, a human homolog of Drosophila Tribbles, has been shown as a critical negative regulator of Akt (also known as protein kinase B), which is a key component in insulin signaling. In addition, TRB3 is another PPAR-target gene and functions as an important link between glucose and lipid metabolism. The Q84R polymorphic variant of TRB3 has been linked to insulin resistance and related clinical...

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Identifiers

PMID: 19291425
DOI: 10.1007/s12020-009-9162-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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