Article
The functional Q84R polymorphism of TRIB3 gene is associated with diabetic nephropathy in Chinese type 2 diabetic patients.
Gene - 25 Jan 2015
Zhang Weiwei, Yang Zhen, Li Xiaoyong, Wen Jie, Zhang Hongmei, Wang Suijun, Wang Xuanchun, Zhou Houguang, Fang Wenjun, Qin Li, Su Qing
Abstract excerpt
Increased oxidative stress and circulating free fatty acids (FFA) has been suggested to involve in the pathogenesis of diabetic nephropathy. TRIB3 can inhibit FFA and reactive oxygen species (ROS) stimulated podocyte production of MCP-1. Smoking increases the production of reactive oxygen species, which accelerates oxidative stress under hyperglycemia. To determine whether the Q84R polymorphism (rs2295490), alone...
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