Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women.

Reproductive biology and endocrinology : RB&E - 14 Apr 2011

Zhang Xue, Fu Li, Zhang Qiufang, Yan Liying, Ma Yanmin, Tu Binbin, Liu Nana, Qiao Jie

Abstract excerpt

BACKGROUND: Tribbles 3 (TRB3) affects insulin signalling by inhibiting insulin-stimulated Akt phosphorylation and subsequent activation. A single nucleotide polymorphism located in the second extron of the human TRB3 gene is thought to be associated with insulin resistance. The latter is a core abnormality in PCOS independent of obesity. The present study was designed to clarify the relationships of TRB3 Q84R...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Blood Glucose
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to Obesity

Share to Polycystic Ovary Syndrome

Share to Protein Serine-Threonine Kinases

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21492415
DOI: 10.1186/1477-7827-9-46
PMCID: PMC3094280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women.PMID 21492415Read ↗

Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.Semantic proximity Read ↗

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.Semantic proximity Read ↗

The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.Semantic proximity Read ↗

Family-Based Association Study of rs17300539 and rs12495941 Polymorphism in Adiponectin Gene and Polycystic Ovary Syndrome in a Chinese Population.Semantic proximity Read ↗

A common variant in the adiponectin gene and polycystic ovary syndrome risk.Semantic proximity Read ↗

Association of polymorphisms in the beta2 and beta3 adrenoceptor gene with polycystic ovary syndrome.Semantic proximity Read ↗

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.Semantic proximity Read ↗

Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women.Semantic proximity Read ↗

Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population.Semantic proximity Read ↗

Association of +45G15G(T/G) and +276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women.Semantic proximity Read ↗

Relationship Between Genetic Polymorphisms in Cell Cycle Regulatory Gene TP53 and Polycystic Ovarian Syndrome: A Case-Control Study and In Silico Analyses.Semantic proximity Read ↗

Relationship between leptin receptor and polycystic ovary syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.