Article
A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism.
Disease models & mechanisms - 19 Dec 2017
Fischer Zachary, Das Rahul, Shipman Anna, Fan Jin-Yuan, Pence Laramie, Bouyain Samuel, Dobens Leonard L
Abstract excerpt
Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to the kinase Akt (Akt1) to block its phosphorylation activation and reduce downstream insulin-stimulated anabolism. A single nucleotide polymorphism (SNP) variant in human TRIB3, which results in a glutamine (Q) to arginine...
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