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Article

The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.

Biochemical Society transactions - 1 Oct 2015

Prudente Sabrina, Trischitta Vincenzo

Abstract excerpt

Insulin resistance is pathogenic for many prevalent disorders including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), polycystic ovary syndrome, non-alcoholic fatty liver disease, Alzheimer's and Parkinson's diseases and several cancers. Unravelling molecular abnormalities of insulin resistance may therefore pave the way for tackling such heavy weight on healthcare systems. This review will be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26517932
DOI: 10.1042/BST20150115

Genes

TRIB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.PMID 26517932Read ↗

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.Semantic proximity Read ↗

TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.Semantic proximity Read ↗

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.Semantic proximity Read ↗

The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.Semantic proximity Read ↗

A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism.Semantic proximity Read ↗

TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion.Semantic proximity Read ↗

Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.Semantic proximity Read ↗

TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.Semantic proximity Read ↗

The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.Semantic proximity Read ↗

Integrative in silico analysis identifies functionally and regulatively relevant nsSNPs in the TRIB3 gene.Semantic proximity Read ↗

Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women.Semantic proximity Read ↗

The role of TRIB1 in lipid metabolism; from genetics to pathways.Semantic proximity Read ↗

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