Article
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.
Diabetes - 1 Sept 2005
Prudente Sabrina, Hribal Marta Letizia, Flex Elisabetta, Turchi Federica, Morini Eleonora, De Cosmo Salvatore, Bacci Simonetta, Tassi Vittorio, Cardellini Marina, Lauro Renato, Sesti Giorgio, Dallapiccola Bruno, Trischitta Vincenzo
Abstract excerpt
Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance. We here report that the prevalent TRB3 missense Q84R polymorphism is...
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