Article
The rs705708 A allele of the ERBB3 gene is associated with lower prevalence of diabetic retinopathy and arterial hypertension and with improved renal function in type 1 diabetic patients.
Microvascular research - 1 Sept 2022
Massignam Eloísa Toscan, Dieter Cristine, Assmann Taís Silveira, Duarte Guilherme Coutinho Kullmann, Bauer Andrea Carla, Canani Luis Henrique, Crispim Daisy
Abstract excerpt
INTRODUCTION: The Erb-b2 receptor tyrosine kinase 3 (ERBB3) is involved in autoimmune processes related to type 1 diabetes mellitus (T1DM) pathogenesis. Accordingly, some studies have suggested that single nucleotide polymorphisms (SNPs) in the ERBB3 gene confer risk for T1DM. Proliferation-associated protein 2G4 (PA2G4) is another candidate gene for this disease because it regulates cell proliferation and...
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