Article
TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2008
Andreozzi Francesco, Formoso Gloria, Prudente Sabrina, Hribal Marta Letizia, Pandolfi Assunta, Bellacchio Emanuele, Di Silvestre Sara, Trischitta Vincenzo, Consoli Agostino, Sesti Giorgio
Abstract excerpt
BACKGROUND: In the endothelium, insulin promotes nitric oxide (NO) production, through the insulin receptor/IRS-1/PI3-Kinase/Akt/eNOS signaling pathway. An inhibitor of insulin action, TRIB3, has recently been identified which affects insulin action by binding to and inhibiting Akt phosphorylation. We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with...
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