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Article

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.

Acta diabetologica - 1 Jun 2009

Prudente Sabrina, Morini Eleonora, Trischitta Vincenzo

Abstract excerpt

Type 2 diabetes is becoming epidemic. The personal and social burden imposed by diabetes will increase in the close future as its prevalence is expected to double in the next 15-20 years. Type 2 diabetes is caused by the combination of resistance to insulin action and inadequate insulin secretion. Despite the role of profound changes in individual environmental exposure is incontrovertible, several findings...

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Source

Identifiers

PMID: 19139803
DOI: 10.1007/s00592-008-0087-y

Genes

TRIB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.PMID 19139803Read ↗

The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.Semantic proximity Read ↗

The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.Semantic proximity Read ↗

Integrative in silico analysis identifies functionally and regulatively relevant nsSNPs in the TRIB3 gene.Semantic proximity Read ↗

A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism.Semantic proximity Read ↗

TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion.Semantic proximity Read ↗

TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.Semantic proximity Read ↗

Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.Semantic proximity Read ↗

Assessment of Human Tribbles Homolog 3 Genetic Variation (rs2295490) Effects on Type 2 Diabetes Patients with Glucose Control and Blood Pressure Lowering Treatment.Semantic proximity Read ↗

The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.Semantic proximity Read ↗

The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.Semantic proximity Read ↗

Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.Semantic proximity Read ↗

The porcine tribbles homolog 3 (TRIB3) gene: Identification of a missense mutation and association analysis with meat quality and production traits in Italian heavy pigs.Semantic proximity Read ↗

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