Article
Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men.
International journal of obesity (2005) - 1 May 2009
Andersson N, Strandberg L, Nilsson S, Ljungren O, Karlsson M K, Mellström D, Lorentzon M, Ohlsson C, Jansson J-O
Abstract excerpt
CONTEXT: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. OBJECTIVE: To systematically investigate our hypotheses that single-nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. SUBJECTS: The Gothenburg osteoporosis and...
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