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Article

Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes.

Metabolism: clinical and experimental - 1 Oct 2010

Luotola Kari, Pietilä Arto, Alanne Mervi, Lanki Timo, Loo Britt-Marie, Jula Antti, Perola Markus, Peters Annette, Zeller Tanja, Blankenberg Stefan, Salomaa Veikko

Abstract excerpt

The natural anti-inflammatory protein interleukin-1 receptor antagonist (IL-1Ra) inhibits the activity of IL-1 and is associated with vascular injury and metabolic disorders. We analyzed genetic and nongenetic determinants of the IL-1Ra phenotype. Fifteen haplotype-tagging single nucleotide polymorphisms (SNPs) in the IL-1α (IL1A), IL-1β (IL1B), and IL-1 receptor antagonist (IL-1RN) genes were determined in the...

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Identifiers

PMID: 20178882
DOI: 10.1016/j.metabol.2010.01.017

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