Article
Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.
Journal of internal medicine - 1 Mar 2011
Luotola K, Pietilä A, Zeller T, Moilanen L, Kähönen M, Nieminen M S, Kesäniemi Y A, Blankenberg S, Jula A, Perola M, Salomaa V
Abstract excerpt
OBJECTIVES: To examine whether interleukin-1 receptor antagonist (IL-1Ra) is a predictor for clinically incident diabetes in subjects with metabolic syndrome (MetS) and whether its predictive power is independent of C-reactive protein (CRP), an established marker of inflammation. We further examined whether genetic variants at the interleukin-1 (IL-1) locus would predict clinically incident diabetes. DESIGN: Two...
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