Article
IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden.
Obesity (Silver Spring, Md.) - 1 Mar 2008
Strandberg Louise, Mellström Dan, Ljunggren Osten, Grundberg Elin, Karlsson Magnus K, Holmberg Anna H, Orwoll Eric S, Eriksson Anna L, Svedberg Johan, Bengtsson Magnus, Ohlsson Claes, Jansson John-Olov
Abstract excerpt
There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study...
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