Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.

doi:10.2337/db14-0731

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Article

Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.

Diabetes - 1 Dec 2014

Herder Christian, Nuotio Marja-Liisa, Shah Sonia, Blankenberg Stefan, Brunner Eric J, Carstensen Maren, Gieger Christian, Grallert Harald, Jula Antti, Kähönen Mika, Kettunen Johannes, Kivimäki Mika, Koenig Wolfgang, Kristiansson Kati, Langenberg Claudia, Lehtimäki Terho, Luotola Kari, Marzi Carola, Müller Christian, Peters Annette, Prokisch Holger, Raitakari Olli, Rathmann Wolfgang, Roden Michael, Salmi Marko, Schramm Katharina, Swerdlow Daniel, Tabak Adam G, Thorand Barbara, Wareham Nick, Wild Philipp S, Zeller Tanja, Hingorani Aroon D, Witte Daniel R, Kumari Meena, Perola Markus, Salomaa Veikko

Abstract excerpt

The proinflammatory cytokine interleukin (IL)-1β is implicated in the development of insulin resistance and β-cell dysfunction, whereas higher circulating levels of IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor of IL-1β, has been suggested to improve glycemia and β-cell function in patients with type 2 diabetes. To elucidate the protective role of IL-1RA, this study aimed to identify genetic...

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PMID: 24969107
DOI: 10.2337/db14-0731
PMCID: PMC4237993

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