Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

doi:10.1016/S2213-8587(15)00034-0

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Article

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

The lancet. Diabetes & endocrinology - 1 Apr 2015

Abstract excerpt

BACKGROUND: To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. METHODS: We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding the IL-1...

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Identifiers

PMID: 25726324
DOI: 10.1016/S2213-8587(15)00034-0
PMCID: PMC4648058

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