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Interleukin-1α gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people.

Clinical chemistry and laboratory medicine - 2 Feb 2012

Zupan Janja, Pristovšek Nuša, Mencej-Bedrač Simona, Komadina Radko, Preželj Janez, Marc Janja

Abstract excerpt

BACKGROUND: Osteoporosis is a skeletal disorder, characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased risk of fracture. Recently, the role of age-related pro-inflammatory cytokines, such as interleukin (IL)-1α, in stimulating bone resorption has been suggested. As osteoporosis has a strong genetic background, the aim of our study was to evaluate the association...

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PMID: 22868802
DOI: 10.1515/cclm-2011-0589

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