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Article

Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.

The Journal of cell biology - 23 Mar 2009

Faza Marius Boulos, Kemmler Stefan, Jimeno Sonia, González-Aguilera Cristina, Aguilera Andrés, Hurt Ed, Panse Vikram Govind

Abstract excerpt

The evolutionarily conserved protein Sem1/Dss1 is a subunit of the regulatory particle (RP) of the proteasome, and, in mammalian cells, binds the tumor suppressor protein BRCA2. Here, we describe a new function for yeast Sem1. We show that sem1 mutants are impaired in messenger RNA (mRNA) export and transcription elongation, and induce strong transcription-associated hyper-recombination phenotypes. Importantly,...

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Identifiers

PMID: 19289793
DOI: 10.1083/jcb.200810059
PMCID: PMC2699155

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.PMID 19289793Read ↗

A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.Semantic proximity Read ↗

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Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.Semantic proximity Read ↗

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.Semantic proximity Read ↗

A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.Semantic proximity Read ↗

SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.Semantic proximity Read ↗

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Functions of Gle1 are governed by two distinct modes of self-associationSemantic proximity Read ↗

Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.Semantic proximity Read ↗

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Semantic proximity Read ↗

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