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Article

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export.

Nucleic acids research - 1 Jun 2014

Jani Divyang, Valkov Eugene, Stewart Murray

Abstract excerpt

The conserved Sac3:Thp1:Sem1:Sus1:Cdc31 (TREX2) complex binds to nuclear pore complexes (NPCs) and, in addition to integrating mRNA nuclear export with preceding steps in the gene expression pathway, facilitates re-positioning of highly regulated actively transcribing genes (such as GAL1) to NPCs. Although TREX2 is thought to bind NPC protein Nup1, defining the precise role of this interaction has been frustrated...

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Source

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Identifiers

PMID: 24705649
DOI: 10.1093/nar/gku252
PMCID: PMC4041426

Genes

TREX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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