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Article

Functions of Gle1 are governed by two distinct modes of self-association

27 Sept 2020

Abstract excerpt

Gle1 is a conserved, essential regulator of DEAD-box RNA helicases, with critical roles defined in mRNA export, translation initiation, translation termination, and stress granule formation. Mechanisms that specify which, where, and when DDXs are targeted by Gle1 are critical to understand. In addition to roles for stress-induced phosphorylation and inositol hexakisphosphate binding in specifying Gle1 function,...

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PMID: 32981894
DOI: 10.1074/jbc.ra120.015715

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