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Article

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.

Molecular and cellular biology - 1 Dec 2002

Zenklusen Daniel, Vinciguerra Patrizia, Wyss Jean-Christophe, Stutz Françoise

Abstract excerpt

Yra1p/REF participates in mRNA export by recruiting the export receptor Mex67p to messenger ribonucleoprotein (mRNP) complexes. Yra1p also binds Sub2p, a DEAD box ATPase/RNA helicase implicated in splicing and required for mRNA export. We identified genetic and physical interactions between Yra1p, Sub2p, and Hpr1p, a protein involved in transcription elongation whose deletion leads to poly(A)(+) RNA accumulation...

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Identifiers

PMID: 12417727
DOI: 10.1128/MCB.22.23.8241-8253.2002
PMCID: PMC134069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.PMID 12417727Read ↗

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Semantic proximity Read ↗

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.Semantic proximity Read ↗

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Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.Semantic proximity Read ↗

The DECD box putative ATPase Sub2p is an early mRNA export factor.Semantic proximity Read ↗

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.Semantic proximity Read ↗

Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism.Semantic proximity Read ↗

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