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Article

The 26S proteasome drives trinucleotide repeat expansions.

Nucleic acids research - 1 Jul 2013

Concannon Claire, Lahue Robert S

Abstract excerpt

Trinucleotide repeat (TNR) expansion is the causative mutation for at least 17 inherited neurological diseases. An important question in the field is which proteins drive the expansion process. This study reports that the multi-functional protein Sem1 is a novel driver of TNR expansions in budding yeast. Mutants of SEM1 suppress up to 90% of expansions. Subsequent analysis showed that Sem1 facilitates expansions...

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Source

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Identifiers

PMID: 23620289
DOI: 10.1093/nar/gkt295
PMCID: PMC3695522

Genes

TNR
PSMB3
PSMC5
SEM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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