Article
Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.
The EMBO journal - 15 Oct 1999
Hodge C A, Colot H V, Stafford P, Cole C N
Abstract excerpt
In a screen for temperature-sensitive mutants of Saccharomyces cerevisiae defective for mRNA export, we previously identified the essential DEAD-box protein Dbp5p/Rat8p and the nucleoporin Rat7p/Nup159p. Both are essential for mRNA export. Here we report that Dbp5p and Rat7p interact through their Nterminal domains. Deletion of this portion of Rat7p (Rat7pDeltaN) results in strong defects in mRNA export and...
Topics
- Adenosine Triphosphatases
- Biological Transport, Active
- Carrier Proteins
- Cell Nucleus
- Cytoplasm
- DEAD-box RNA Helicases
- Fungal Proteins
- Karyopherins
- Membrane Proteins
- Mutation
- Nuclear Pore Complex Proteins
- Nuclear Proteins
- Nucleocytoplasmic Transport Proteins