SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.

doi:10.1073/pnas.96.3.909

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Article

SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 1999

Jäntti J, Lahdenranta J, Olkkonen V M, Söderlund H, Keränen S

Abstract excerpt

The exocyst is an essential multiprotein complex mediating polarized secretion in yeast. Here we describe a gene, SEM1, that can multicopy-suppress exocyst mutants sec3-2, sec8-9, sec10-2, and sec15-1. SEM1 is highly conserved among eukaryotic species. Its human homologue, DSS1, has been suggeste...

Topics

Amino Acid Sequence
Animals
Cell Cycle Proteins
Cell Differentiation
Databases as Topic
Evolution, Molecular
Exocytosis
Fungal Proteins
Gene Deletion
Genes, Fungal
Genotype
Glycoside Hydrolases
Humans
Mice
Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 9927667
DOI: 10.1073/pnas.96.3.909
PMCID: PMC15324

Genes

SEM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927667-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phylogeny

Proteasome Endopeptidase Complex

Proteins