Article
Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Cui Jing, Taylor Kimberly E, Destefano Anita L, Criswell Lindsey A, Izmailova Elena S, Parker Alex, Roubenoff Ronenn, Plenge Robert M, Weinblatt Michael E, Shadick Nancy A, Karlson Elizabeth W
Abstract excerpt
We carried out a genome-wide association study of genetic predictors of anti-cyclic citrullinated peptide antibody (anti-CCP) level in 531 self-reported non-Hispanic Caucasian Rheumatoid Arthritis (RA) patients enrolled in the Brigham Rheumatoid Arthritis Sequential Study (BRASS). For replication, we then analyzed 289 single nucleotide polymorphisms (SNPs) with P < 0.001 in BRASS in an independent population of...
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