New insights into the genetics of immune responses in rheumatoid arthritis.

doi:10.1111/j.1399-0039.2012.01939.x

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Article

New insights into the genetics of immune responses in rheumatoid arthritis.

Tissue antigens - 1 Aug 2012

Ruyssen-Witrand A, Constantin A, Cambon-Thomsen A, Thomsen M

Abstract excerpt

Rheumatoid arthritis (RA) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti-citrullinated protein antibodies (ACPAs) has become a hallmark for the diagnosis and prognosis of RA. The post-translational transformation of arginine residues of proteins and peptides into...

Topics

Arthritis, Rheumatoid
Autoantibodies
Autoimmunity
Biomarkers
Citrulline
Gene Expression
Genetic Loci
Genome-Wide Association Study
HLA-DRB1 Chains
Humans
Polymorphism, Single Nucleotide
Protein Processing, Post-Translational
Risk Factors
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 22835281
DOI: 10.1111/j.1399-0039.2012.01939.x

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