Article
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
Annals of the rheumatic diseases - 1 Mar 2015
Bossini-Castillo L, de Kovel C, Kallberg H, van 't Slot R, Italiaander A, Coenen M, Tak P P, Posthumus M D, Wijmenga C, Huizinga T, van der Helm-van Mil A H M, Stoeken-Rijsbergen G, Rodriguez-Rodriguez Luis, Balsa Alejandro, González-Álvaro Isidoro, González-Gay Miguel Ángel, Gómez-Vaquero Carmen, Franke B, Vermeulen S, van der Horst-Bruinsma Ie, Dijkmans B A C, Wolbink G J, Ophoff R A, Maehlen M T, van Riel P, Merriman M, Klareskog L, Lie B A, Merriman T, Crusius J B A, Brouwer E, Martin J, de Vries N, Toes R, Padyukov L, Koeleman B P C
Abstract excerpt
INTRODUCTION: Rheumatoid arthritis (RA) patients can be classified based on presence or absence of anticitrullinated peptide antibodies (ACPA) in their serum. This heterogeneity among patients may reflect important biological differences underlying the disease process. To date, the majority of genetic studies have focused on the ACPA-positive group. Therefore, our goal was to analyse the genetic risk factors that...
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