HLA-B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti-Carbamylated Protein Antibody-Positive/Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

doi:10.1002/art.41630

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HLA-B*08 Identified as the Most Prominently Associated Major Histocompatibility Complex Locus for Anti-Carbamylated Protein Antibody-Positive/Anti-Cyclic Citrullinated Peptide-Negative Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2021

Regueiro Cristina, Casares-Marfil Desire, Lundberg Karin, Knevel Rachel, Acosta-Herrera Marialbert, Rodriguez-Rodriguez Luis, Lopez-Mejias Raquel, Perez-Pampin Eva, Triguero-Martinez Ana, Nuño Laura, Ferraz-Amaro Ivan, Rodriguez-Carrio Javier, Lopez-Pedrera Rosario, Robustillo-Villarino Montse, Castañeda Santos, Remuzgo-Martinez Sara, Alperi Mercedes, Alegre-Sancho Juan J, Balsa Alejandro, Gonzalez-Alvaro Isidoro, Mera Antonio, Fernandez-Gutierrez Benjamin, Gonzalez-Gay Miguel A, Trouw Leendert A, Grönwall Caroline, Padyukov Leonid, Martin Javier, Gonzalez Antonio

Abstract excerpt

OBJECTIVE: Previously, only the HLA-DRB1 alleles have been assessed in rheumatoid arthritis (RA). The aim of the present study was to identify the key major histocompatibility complex (MHC) susceptibility factors showing a significant association with anti-carbamylated protein antibody-positive (anti-CarP+) RA. METHODS: Analyses were restricted to RA patients who were anti-cyclic citrullinated peptide antibody...

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PMID: 33381897
DOI: 10.1002/art.41630

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