Article

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate

2023-04-05

Abstract excerpt

Cancer somatic mutations are the product of multiple mutational and repair processes, both of which are tightly associated with DNA replication. Mutation rates (MR) are known to be higher in late replication timing (RT) regions, but different processes can affect this association. Systematic analysis of the mutational landscape of 2,787 tumors from 32 tumor types revealed that approximately one third of the tumor...

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Literature Corpus work: 87a07821-3ac9-5104-8017-935a1db25ac6
DOI: 10.21203/rs.3.rs-2633822/v1

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