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Article

Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae.

Current biology : CB - 16 Apr 2002

Devault Alain, Vallen Elizabeth A, Yuan Tina, Green Stephen, Bensimon Aaron, Schwob Etienne

Abstract excerpt

Faithful duplication of the genetic material requires that replication origins fire only once per cell cycle. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. In all eukaryotes studied, this entails loading by Cdc6 of the Mcm2-7 helicase next to the origin recognition complex (ORC). More recently, another factor, named Cdt1, was...

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PMID: 11967159
DOI: 10.1016/s0960-9822(02)00768-6

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