Article
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state.
Current biology : CB - 1 Nov 1995
Dahmann C, Diffley J F, Nasmyth K A
Abstract excerpt
BACKGROUND: DNA replication and mitosis are triggered by activation of kinase complexes, each made up of a cyclin and a cyclin-dependent kinase (Cdk). It had seemed possible that the association of Cdks with different classes of cyclins specifies whether S phase (replication) or M phase (mitosis)...
Topics
- Cell Cycle
- Cloning, Molecular
- Cyclin B
- Cyclin-Dependent Kinases
- Cyclins
- DNA Replication
- G2 Phase
- Gene Expression Regulation
- Mutation
- Nocodazole
- Replication Origin
- S Phase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins