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Article

Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Journal of Alzheimer's disease : JAD - 1 Jan 2009

Ma Linqing, Ohyagi Yasumasa, Miyoshi Katsue, Sakae Nobutaka, Motomura Kyoko, Taniwaki Takayuki, Furuya Hirokazu, Takeda Kazuya, Tabira Takeshi, Kira Jun-ichi

Abstract excerpt

Presenilin 1 (PS1) gene mutations are the major causes of early-onset familial Alzheimer's disease and are known to increase amyloid-beta42 (Abeta42) production as well as to promote apoptosis. We have recently reported that intracellular Abeta42 activates p53 mRNA expression and promotes p53-dependent apoptosis. Here, we examined the p53 mRNA and protein levels in cells transfected with wild-type and I143T/G384A...

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Identifiers

PMID: 19276551
DOI: 10.3233/JAD-2009-0990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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