Article
Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002
Alves da Costa Cristine, Paitel Erwan, Mattson Mark P, Amson Robert, Telerman Adam, Ancolio Karine, Checler Frédéric, Mattson Marc P
Abstract excerpt
Presenilins 1 and 2 are two homologous proteins that, when mutated, account for most early onset Alzheimer's disease. Several lines of evidence suggest that, among various functions, presenilins could modulate cell apoptotic responses. Here we establish that the overexpression of presenilin 2 (PS...
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