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Article

Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation.

Molecular neurobiology - 1 Feb 2014

Tung Ying-Tsen, Wang Bo-Jeng, Hsu Wen-Ming, Hu Ming-Kuan, Her Guor Mour, Huang Wei-Pang, Liao Yung-Feng

Abstract excerpt

Mutations in presenilin-1 (PS1) are tightly associated with early-onset familial Alzheimer's disease (FAD), which is characterized by extracellular amyloid plaques and the accumulation of intracellular Tau. In addition to being the catalytic subunit of γ-secretase, PS1 has been shown to regulate diverse cellular functions independent of its proteolytic activity. We found that cells deficient in PS1 exhibit...

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PMID: 23794287
DOI: 10.1007/s12035-013-8482-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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