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Article

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Jun 2006

Alves da Costa Cristine, Sunyach Claire, Pardossi-Piquard Raphaelle, Sévalle Jean, Vincent Bruno, Boyer Nicole, Kawarai Toshitaka, Girardot Nadège, St George-Hyslop Peter, Checler Frédéric

Abstract excerpt

Presenilins (PSs) are part of the gamma-secretase complex that produces the amyloid beta-peptide (Abeta) from its precursor [beta-amyloid precursor protein (betaAPP)]. Mutations in PS that cause familial Alzheimer's disease (FAD) increase Abeta production and trigger p53-dependent cell death. We demonstrate that PS deficiency, catalytically inactive PS mutants, gamma-secretase inhibitors, and betaAPP or amyloid...

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Identifiers

PMID: 16763046
DOI: 10.1523/JNEUROSCI.0651-06.2006
PMCID: PMC6675197

Genes

APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.PMID 16763046Read ↗

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