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Article

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1and results in apoptosis and tumor suppression

1 Jul 1998

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9662377
DOI: 10.1038/nm0798-835

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1and results in apoptosis and tumor suppressionPMID 9662377Read ↗

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Semantic proximity Read ↗

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 ExpressionSemantic proximity Read ↗

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.Semantic proximity Read ↗

Presenilins: Genes for Life and DeathSemantic proximity Read ↗

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient miceSemantic proximity Read ↗

Presenilins: molecular switches between proteolysis and signal transductionSemantic proximity Read ↗

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.Semantic proximity Read ↗

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.Semantic proximity Read ↗

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Semantic proximity Read ↗

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cellsSemantic proximity Read ↗

Presenilin-1: a component of synaptic and endothelial adherens junctions.Semantic proximity Read ↗

Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryosSemantic proximity Read ↗

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