Article
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice
9 May 2000
Abstract excerpt
Presenilin 1 (PS1) expression is repressed by the p53 tumor suppressor. As shown herein, wild-type PS1 is an effective antiapoptotic molecule capable of significantly inhibiting p53-dependent and p53-independent cell death. We analyzed, at the functional and molecular levels, the brains of p53 knockout mice. Surprisingly, we found that lack of p53 expression induces apoptotic brain lesions, accompanied by...
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