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Article

Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Journal of Alzheimer's disease : JAD - 1 Jan 2009

Miyoshi Katsue, Ohyagi Yasumasa, Sakae Nobutaka, Motomura Kyoko, Ma Linqing, Taniwaki Takayuki, Furuya Hirokazu, Tabira Takeshi, Kira Jun-ichi

Abstract excerpt

Presenilin 1 (PS1) gene mutations are the major causes of early-onset familial Alzheimer's disease. Acceleration of apoptosis is one of the major pathogenic mechanisms of PS1 mutants, and PS1 mutants have also been reported to induce overproduction of amyloid-beta protein 42. Here, we investigated aberrancy in activation of initiator caspases related to two PS1 gene mutations, I143T and G384A. Acceleration of...

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Identifiers

PMID: 19276550
DOI: 10.3233/JAD-2009-0989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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